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5 Free-radicals are charged atoms that can react with molecules

Preclinical studies consistently demonstrate its ability to reduce oxidative stress, modulate inflammatory cascades, and protect BBB integrity 81

In a pig model of renal IRI injury, the treatment with C1-INH conferred protection not only blocking C4d, factor B, C5b-9 deposition but also reducing infiltrating cells, significantly modulating early fibrosis by limiting number of myofibroblasts through endothelial-to-mesenchymal (EndMT), pericytes-to-myofibroblasts (PMT) transitions (56, 65, 66) leading to a reduction of chronic graft fibrosis also after 3 months from transplantation (55)

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