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Although the relative frequency of neutrophils decreased in the later stages of smoke-induced lung inflammation, they remained a key source of pro-inflammatory mediators, as exemplified by the strong expression of various chemokines ( Cxcl2 , Ccl3 , Ccl4 , Cxcl10 ) as well as Tnf and Il1b ( Figure 6D )

However, the act was set to commence on April 1 to give manufacturers and retailers time to adapt to the new guidelines

An estimated 700,000 premature deaths are caused by smoking each year, and cancer charities are backing the measures

John Barned-Smith and Gabrielle Banks contributed