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Antimicrobial Agents Chemotherapy 50, 419842015

Besides the lncRNA-mediated signal, M2 macrophage-secreted EVs have even been reported to have a direct promoting angiogenesis effect, via HIF-1/VEGFA signaling, which further highlights the pro-tumorigenic nature of macrophage-secreted EVs (85)

Holistic view and syndrome differentiation are the theoretical guidance of TCM and reflect system physiology approaches and personalized medicine in Western medicine [7], demonstrating their advantages in NAFLD treatment [8]