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10.1124/jpet.108.143578 86 ReichenJ.BerrF.LeM.WarrenG

------------------------ Hyaluronic Acid: Hyaluronic acid, also known as HA, is a natural compound found in skin that has many important functions, including holding in moisture, providing cushioning, adding in tissue repair, and holding together the skin's structural components (collagen and elastin)

Subsequent membrane depolarization triggers the opening of voltagegated calcium channels, leading to a localized influx of Ca 2+ , The binding of calcium to synaptotagmin serves as the molecular trigger for the rapid fusion of synaptic vesicles and exocytotic release of dopamine into the synaptic cleft [193]