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Studies suggest that it: Promotes fat breakdown by activating beta-3 adrenergic receptors, leading to the release of fatty acids

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Most research protocols run 8 to 12 weeks, followed by a break period of 4 to 6 weeks

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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose