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The results indicated that DZN exposure led to excessive reactive oxygen species (ROS) production and DNA damage, ultimately inducing apoptosis and autophagy by inhibiting the PI3K-Akt pathway [15]

Different cell lines were previously shown to vary in their allicin susceptibilities, which correlated with their intracellular GSH levels ( S -thioallylation of GSH and the formation of S -allylmercaptoglutathione (GSSA), which is accompanied by GSH depletion and an oxidative shift in the GSH redox potential ( Since Vero E6 cells are more sensitive toward allicin compared to Calu-3 cells, we first analyzed the effect of low levels of 50 M allicin on SARS-CoV-2 infected Vero E6 cells using pre- and post-infection treatments of host cells or pre-exposure of the virus before infection

19 Several cellular receptors and targets have been studied to understand the cellular pathways and molecular targets for targeted therapy, such as using small interfering RNA (siRNA) as a therapeutic substance to downregulate these signalling-specific genes 20,21