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Contemporary smart hydrogels go further by responding to multiple endogenous cues (enzymes, reactive oxygen species, pH, temperature) and exogenous cues (light, electricity, magnetism, ultrasound, mechanical force) with spatiotemporal control

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Wild type SOD1 can be misfolded by the aberrant translation, post-translational modification or oxidative modifications, due to the pathological conditions of the CNS environment, and produce toxic insoluble aggregates, as mutated SOD1 (Durazo et al., 2009)