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Use of APAP is considered to be safe in therapeutic concentrations but can cause liver damage after an overdose, ultimately leading to ALF in severe cases [14]

Nutrients 9(2):158

BVZ in combination with other cytotoxic drugs like carboplatin and etoposide also showed therapeutic benefit in clinical trials but is yet to be approved by FDA

Other drugs affect the cycle at different points including flucloxacillin which inhibits 5-oxoprolinase similarly resulting in build-up of 5-oxoproline