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MMP-9 produced by neutrophils disrupts the integrity of the BBB effectively exacerbating pathologic neuroinflammation

Additionally, the inhibition of LRRK2 has been linked to reduced ferroptotic damage via the p62/Keap1/NRF2 axis (132) and teneligliptin, a dipeptidyl peptidase-4 inhibitor, decreases ROS levels and prevents ferroptosis (133)