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siRNA or miRNA constructs Two problems currently faced by siRNA or miRNA constructs are, first, their susceptibility to nuclease digestion in plasma and, second, their limited ability to gain access to the intracellular compartment where they can bind RISC when administered systemically as the free siRNA or miRNA

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PubMed Wilson RD, Caughey AB, Wood SL, Macones GA, Wrench IJ, Huang J, et al

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