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This oxidative crisis leads to red blood cell destruction, a key concern in malaria treatment and CSIR NET life sciences exams. Primaquine Mechanism in Hemolysis Primaquine treats Plasmodium vivax relapses but its quinone metabolites like 5,6-POQ generate ROS, oxidizing hemoglobin and GSH

Rare Systemic Adverse Effects Even though they are rare, some people might experience systemic side effects

Plitman E, Iwata Y, Caravaggio F, Nakajima S, Chung JK, Gerretsen P et al (2017) Kynurenic acid in schizophrenia: a systematic review and meta-analysis

In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers

Currently, sodium thiosulfate is an FDA approved medicine used for treating acute cyanide poisoning, carbon monoxide toxicity, and calcific uremic arteriolopathy found in dialysis patients [38,40,[42], [43], [44],48,51]