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Experimental data suggest that the number of CSC can vary between tumors, even those with the same histopathological type and that a higher percentage of cancer stem cells are associated with higher radioresistance

(Peptide Gurus) By mimicking the part of FOXO4 that binds p53, FOXO4-DRI competes for that interaction, frees p53, causes its nuclear exclusion and triggers apoptosis in the senescent cell, thereby selectively reducing senescent cell burden

ASC specks exacerbate synuclein pathology via amplifying NLRP3 inflammasome activities