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These and other findings have led to the currently predominant view of ROS as important signaling molecules

Simultaneously, anti-inflammatory cytokines such as TGF-, GDF-5, GDF-6, IL-4, and IL-10 are also present in the degenerative environment and can, to some extent, delay degeneration and alleviate pain (Wang et al., 2016), with their balance potentially closely related to the polarization state of macrophages (Yamamoto et al., 2022

433 The adipocytes of Friedreichs ataxia mice showed significantly reduced GPX4 expression, increased lipid peroxides, and significantly increased sensitivity to ferroptosis