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have revealed that angiotensin II stimulated NADPH oxidase activity in VSMCs, leading to superoxide (O2-) and H2O2 generation (41)

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Notably, postnatal use up to 18 months was not associated with these outcomes

Beyond simple biomechanics, where each 1 kg of weight gain multiplies knee joint load by 34 kg, accelerating cartilage wear and activating pathogenic pathways like Wnt/ -catenin, the endocrine function of fat is paramount (14, 15)