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If you experience severe side effects (debilitating fatigue, complete insomnia, significant mood disruption) beyond expected mild rebound suppression, restarting at 50% dose every 72 hours for 10-14 days can provide a bridge while your axis recovers

A high level of TGTP is desired, as it has a high affinity toward Rac1, and should lead to favorable treatment outcomes (Neurath et al., 2005)

Hypothalamic AT 1 -receptor activation and endotoxin-mediated TLR activation, as occurs in sepsis leads to increased hypothalamic NOX and NFB activity, which in turn has been shown to deleteriously affect autonomic tone and cardiac remodeling (300)