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Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

doi: 10.1038/cddis.2016.493 46 ZhouSJDengYLLiangHFJaoudeJCLiuFY

52 Gap-junction-mediated signalling between astrocytes and MDA-MB-231 cells also upregulates the expression of IL-6 and IL-8, leading to an increase in the production of endothelin-1 (ET-1) from astrocytes and the expression of the ET receptor on the tumour cells

Fe 2+ aggregates exhibited high phototoxicity (808 nm, 0.4 W cm 2 , 10 min), with a 90 M dose of Fe 2+ aggregates resulting in the death of over 80% of 4T1 cells, whereas Mn 2+ aggregates and free dye only caused approximately 70% and 20% cell death, respectively