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Conversely, high-dose zinc supplementation in mice colonized with Clostridium difficile alters microbial composition and exacerbates disease severity by increasing toxin production and disrupting immune responses (Zackular et al., 2016)

This also assisted in inhibiting the increase of urea nitrogen and creatinine levels (46)

Thirteen biologics were identified, with an even split between preclinical and clinical research

Due to the heterogeneity of the molecules considered and the laboratory methodologies, it was not possible to perform a meta-analysis, and the main results are reported in Table 1