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special warnings Take special care with NICOTINELL FRUIT 2 mg SUGAR-FREE, medicated chewing gum: Consult your doctor or pharmacist if you: cardiovascular disease, eg myocardial infarction, heart failure, angina pectoris, Prinzmetal angina, heart rhythm disorder, history of stroke, high blood pressure, circulatory problems, hepatic or renal insufficiency, thyroid disease (hyperthyroidism), diabetes (follow your blood glucose more often at the beginning of the treatment as it can be altered), pheochromocytoma ( disease of the adrenal glands causing severe hypertension ), inflammation of the mouth or throat, esophagitis, gastritis, ulcer of the stomach or duodenum

There was little evidence to support the hypothesis that low MAO levels/activity is a predictive factor for tobacco use

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Their prevalence rates differ somewhat as well