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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a polyphenol derived from the rhizomes of C

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This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342345 , while SIRT5 maintains glycolysis 346

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This design integrates homotypic tumor targeting (conferred by the cancer cell membrane cloak) with mitochondrial targeting (TPP) (Figure 12)

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