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Furthermore, research indicates that trans- 3-indoleacrylic acid (IDA), a tryptophan metabolite originating from anaerobic peptostreptococcus , serves as an internal ligand for the aryl hydrocarbon receptor (AhR)

Glutamine Metabolism Pathways TCA Cycle and IDH2 In the TCA cycle, glutamine-derived -ketoglutarate converts to isocitrate and citrate

doi: 10.1371/journal.pone.0196921 90 YangMChenXHuXLiHHuangHFangYet al

240 IDO1 is a critical enzyme in the tryptophankynurenine pathway and has been identified as a promising immunomodulatory target

Simultaneously, insulin resistance, both at the hepatic and systemic level, exacerbates lipid accumulation and impairs glucose homeostasis, compounding the metabolic burden