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This initial recognition not only triggers epithelial cell-autonomous responses (e.g., barrier reinforcement, secretion of proinflammatory cytokines) but also primes the subsequent recruitment and activation of innate immune cells

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Moreover, vascular endothelial cells in the breast cancer microenvironment release several miRNAs ( miR-142-5p , miR-183-5p , and miR-222-3p ) that are transported through extracellular vesicles, and subsequently regulate macrophage remodeling and promote macrophage polarization toward the M2 phenotype 73 ( Figure 3H )

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