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coli (facultative anaerobe) prior to irradiation did not affect the relative radio-resistance of the germ-free mice, indicating that these species were not responsible for the radiation sensitivity of the mice with normal gut flora

The main theoretical concern is angiogenesis BPC-157 promotes new blood vessel formation, which is great for healing but theoretically undesirable if you have a condition where blood vessel growth is problematic (active cancer is the primary example)

Mikus et al., 2001