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In comparison, three additional strains ( L.plantarum MSD74, L

including 768 healthy controls, 133 patients with mild cognitive impairment, and 211 Alzheimer disease patients) found a U-shaped relation between RBC folate and plasma tHcy, such that higher tHcy was observed with the lowest and highest RBC folate concentrations compared with intermediate concentrations

Dysregulation of this axis leads to a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

Sequencing was performed on an Illumina NovaSeq 6000 platform, producing paired-end reads of 150 bp

Early recognition and intervention may prevent chronic remodeling and improve long-term outcomes for this growing patient population