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13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

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The researchers monitored the effect of FOXO4-DRI on a group of aged laboratory mice, noting a significant decrease in the number of senescent Leydig cells and a parallel increase in the concentration of testosterone in the blood plasma

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