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265 Interestingly, -3PUFA also directly upregulates 15-PGDH which acts as a tumor suppressor in lung and colon cancer

10.1038/mi.2014.35 8 ChenJ.XuF.RuanX.SunJ.ZhangY.ZhangH.et al (2023a)

From 2005 to 2014, it is estimated that the rate of US emergency department (ED) visits due to opioids doubled from 89.1 per 100,000 people to 177.7 per 100,000 (Agency for Healthcare Research and Quality, www.tinyurl.com/2xr8hp8h)