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Also, the cumulative need for colectomy after 10 years was 9.8%, nearly 50% of the patients were relapse-free in the last five years of the study, and only 20% of the patients with proctitis or left-sided disease progressed to pancolitis

Annu Rev Pharmacol Toxicol 53: 401-426

To independently confirm this observation, we examined primary Atm / mouse embryonic fibroblasts (MEFs) and found that these constitutively null cells display a chronic accumulation of intracellular glutamate compared to controls (Fig

W.KntgenF.et al (1999)

Diabetes Care 22:20942095 Izumino K, Sakamaki H, Ishibashi M, Takino H, Yamasaki H, Yamaguchi Y, Chikuba N, Matsumoto K, Akazawa S, Tokuyama K, et al (1997) Troglitazone ameliorates insulin resistance in patients with Werners syndrome