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For example, 50 nm silica nanoparticles showed the highest tumor accumulation out of particles sized 20, 50, and 200 nm in a muse primary and metastatic breast cancer model 52 , whereas 30 nm micelles were reported to be optimal for a poorly permeable pancreatic tumor model in mice 46

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These can trap heat and bacteria in the skin instead of letting it breathe and cool downcompletely defeating the purpose of using aloe in the first place