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Providentially, the evidence collected by Cook and co-authors in 2019 by co-administering paracetamol and mefenamic acid to an adult male implicitly validates our metric: they proved that a known SULT1A1 inhibitor reduced the generation of paracetamol sulfate, so we can infer PSI is sensitive to enzymatic inhibition

Transforming growth factor 1 null mutation in mice causes excessive inflammatory response and early death

Berberine is a natural plant compound found in several herbs, including barberry, goldenseal, and Oregon grape

Seamless raster grid from national and sub-national administrative datasets To ensure that our gridded end-products cover the entire land area included in the input datasets, we created a seamless administrative raster file using national (and in some cases also autonomous areas such as Greenland) and sub-national boundaries, and two population datasets (see Table 2)

In the first step of analysis with milk CORT as a dependent variable, common factors such as maternal BMI, child age, number of feedings, and RLCQ postnatal were included as independent continuous variables in the null model