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In a 36-week phase II RCT, patients receiving 80 mg resmetirom per day had significantly reduced hepatic lipid accumulation, but transient mild diarrhea and nausea were also more common [208]

Bossy M

Gibson, R

doi: 10.1007/s00109-016-1404-5

The FTO rs9939609 and MC4R rs17782313 variants, for example, influence your baseline appetite signaling and metabolic rate, which directly impacts how aggressively semaglutide will suppress your hunger and how quickly you'll adapt to smaller meal sizes