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But all that is to say we still have these modifiable risk factors, which, you know, according to the last Lancet Commission on dementia prevention, there are 14 of them

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid- peptide

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Developing TME-responsive targeted delivery systems and combining ferroptosis inducers with immune checkpoint inhibitors or CAF inhibitors can enhance therapeutic efficacy and reduce toxicity ( In summary, ferroptosis holds great potential for the treatment of digestive tract tumors, but its clinical translation relies on in-depth deciphering of the interaction mechanisms between TME, immunity, and ferroptosis