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Serious risks include potential thyroid C-cell tumors (Zepbound is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), acute pancreatitis, gallbladder disease, and hypoglycemia when used with insulin or insulin secretagogues

[] Sirt3 knockout exacerbates mtMOF-induced mitochondrial damage, cardiac remodeling, and HF progression

Body composition changes from preserved muscle mass develop over months rather than weeks

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