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IL-6, a key proinflammatory cytokine, is upregulated in multiple OA-related joint compartments, including synovial tissue, cartilage, and synovial fluid, where it promotes matrix degradation and inflammation (39)

GHK Basic Studies on Insulin-Related Genes and Cellular Longevity Research indicates that GHK may modulate insulin and insulin-like gene expression, possibly impacting cellular lifespan