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ITPA Activity in Adults and Children Treated with or without Azathioprine: Relationship between TPMT Activity, Thiopurine Metabolites, and Co-medications

Fang J, Wu H, Zhang J, Mao S, Shi H, Yu D, Chen Z, Su K, Xing Y, Dong H, Shi H

Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis (68)