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Garcia-Manero G, Bose P, Alvarado Y, Borthakur G , Daver N, Ravandi-Kashani F, Jabbour E, Takahashi K, Andreeff M, Kadia T, DiNardo C, Cortes J, Kornblau S, Naqvi K, Benton C, Ohanian M, Konopleva M, Estrov Z, Montalban Bravo G, Pierce S, Bodden K, Kantarjian H

The RPE can perform de novo cholesterol synthesis as cholesterol synthesis pathway genes, such as HMGCR, DHCR24, and SQLE, are expressed in human and mouse RPE (Zheng et al., 2012, 2015

The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption, abundant polyunsaturated fatty acids, and relatively modest antioxidant defenses compared to other organs [1][2][48]

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"Generally intravenously is the more efficient way to administer something," agrees Dr Gravaghi