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Menopause: Hormonal fluctuations during menopause may result in skin darkening

It is generally used for 3 months before considering a surgical referral, the latter performed for cosmetic reasons and only in stable cirrhosis patients after weighing risk to benefit ratio ( Symptomatic skin changes that are part of patient-related complaints mostly include localized or generalized hyperpigmentation and darkening over face or body parts

Activated microglia release pro-inflammatory cytokines and chemokines, with lactate enhancing this inflammatory response (Calsolaro and Edison, 2016)

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