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We then utilized this DeepContrast technique to study brain aging and Alzheimer's disease, applying it to both in-house datasets from an aging study, as well as to the publicly available ADNI dataset from Alzheimer's patients and age-matched controls

Notably, we observed lower levels of tissue coenzyme A (CoA), which has been considered to be extremely stable 10 , resulting in reduced mitochondrial functionality and metabolic rewiring

It can be taken as part of a structured routine and used alongside other products depending on personal preferences

FIGURE 1 Cell culture The cell line of HRMCs was purchased from the Chinese Academy of Sciences, Shanghai Institute for Biological Sciences Cell Resource Center

Kinetic constants were determined using 65 kDa for the molecular weight of laccase estimated by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS 22