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Unfortunately, a clinical trial evaluating drugs targeting the IL-1 pathway, such as anakinra, for the treatment of AH, yielded negative results [135]

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In the present study, we found that high doses of iron decreased the survival rate of mice after 8 weeks of feeding, which may be related to high-iron induced liver injury as well as other internal organ lesions [33]

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In addition, upregulated expression of TXNIP (Thioredoxin Interacting Protein, TXNIP) in LSEC has a protective effect in improving ALD

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