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The neurons in the affected network compensate for this weak or absent signals by increasing the number of neuro-transmitter receptors

If NDC2 was subsequently assigned to a new HCPCS code Y0000, the first marketed date for HCPCS Y0000 would similarly be January 15, 2022, because that is the earliest date of first sale for any NDC (NDC1) marketed under any NDA (NDA 000000) under which any NDC ever assigned to HCPCS code Y0000 (NDC2) was marketed