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& Stephanopoulos, G

doi:10.23736/S0026-4725.16.04008-1 Belcaro G, Cesarone MR, Scipione C, et al

(Sparky House Publishing, 2014)

Arch Med Vet 46:299304

Substantial evidence confirms that gut barrier dysfunction-induced microbial imbalance facilitates bacterial endotoxin (e.g., LPS) translocation across the intestinal epithelium into systemic circulation, precipitating metabolic endotoxemia - a process driving multi-tissue injury through systemic inflammatory responses (Saad et al., 2016)