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V289A, R233C, A199T, R153C are potential deleterious nsSNPs (Table 1)

These shifts indicate misfolded protein accumulation and associated cardiac dysfunction in RCM and suggest that proteomic and metabolomic profiling can differentiate CA subtypes and may complement or reduce reliance on invasive biopsy

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Trajectory inference and pseudo-temporal ordering Monocle 3 was used to construct a trajectory upon UMAP embeddings and order cells in pseudotime 99

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