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Thats the actual reason to think about a break with oral GHK-Cu its a mineral interaction question, not a receptor question

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Fifty years of research

(If YES, contraindicated) What To Do If Adverse Reaction Occurs - **Mild irritation or dryness**: Reduce application frequency and use a hydrating moisturizer.- **Persistent redness or sensitivity**: Discontinue use for 3-5 days and reintroduce at a lower frequency.- **Severe allergic reaction (rare)**: Discontinue immediately and provide appropriate medical care

The formulation is intended to trigger controlled exfoliation while supporting overall skin health, which allows it to be used on a wide range of skin types and tones when administered properly