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Stage III (72-96 hours) = Maximal stage of hepatotoxicity = Hepatic failure Clinical features Recurrence of systemic symptoms (anorexia, nausea, vomiting, malaise) Emerging signs & symptoms of hepatic failure : Encephalopathy, jaundice, coagulopathy, hypoglycemia, lactic acidosis, shock

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

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To be clinically actionable, a variant must be associated with a phenotype of sufficient severity and account for a substantial proportion of cases determined by its effect size and MAF (Supplementary Fig