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elegans has six known serotonin receptors: two serotonin-gated ion channels (MOD-1, a chloride channel, and LGC-50, a cation channel), and four G-protein coupled receptors (SER-5 (Gs-coupled), SER-7 (Gs-coupled), SER-1 (Gq-coupled) and SER-4 (Gi/o-coupled)) (Fig