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Signal Transduction and Targeted Therapy 6, 49

Mechanism of Action (Based on Preclinical and Clinical Research): Mimics endogenous GHRH by binding to pituitary GHRH receptors Stimulates pulsatile secretion of GH, preserving physiological release patterns Increases circulating IGF-1 levels, mediating many of its metabolic and anabolic effects Supports lipolysis and lipid redistribution via GH/IGF-1 axis modulation Potential Benefits (Based on Preclinical Research): Enhanced growth hormone and IGF-1 activity in research models Studied for effects on reducing visceral adipose tissue (VAT) Investigated for improvements in body composition and metabolic regulation Potential research applications in models of age-related decline in GH secretion For Research Use Only

doi: 10.1038/s41598-019-45164-5 54 BaekSHLiAHSassettiCM

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