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The accumulation of altered key tumor suppressor genes such as TP53 and CDKN2A, which encode p53 and p16INK4A, respectively is associated with the onset, progression and poor prognosis of HPV-negative HNSCC

Neurogenesis involves cell proliferation, migration and differentiation (46)

In the context of GLP-1 analogs, nanoformulations have shown significant promise in addressing their inherent pharmacokinetic limitations

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Dati tossicologici preclinici: Studi di tossicit acuta e subacuta nei ratti non hanno rivelato mortalit o tossicit significativa a livello degli organi, anche a dosi ben superiori a quelle terapeutiche (fino a 100 volte la dose efficace)