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To optimize Cu catalytic site, it is necessary to reduce the overall energy of Cu 2+ coordination environment and particularly the energy required to break one of the Cu 2+ -related coordination bond 30,31

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They also demonstrated a significant reduction in DNA damage through the stimulation of DNA repairs

Under conditions of oxidative stress, inflammation, and other harmful stimuli, TXNIP can be activated, leading to increased cholesterol synthesis and metabolism by inhibiting the antioxidant activity of TRX and promoting NLRP3 inflammasome activation 41

No prospective randomized trials are available on this matter