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Seventy-seven young and healthy volunteers assigned male at birth, some living in urban areas and some living in rural areas, were recruited in the trial

270 Moreover, H 2 O 2 was also shown to mediate NF-kB activation in an IKK-dependent way by regulating the PI3K/PTEN/AKT signaling cascade

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doi: 10.3389/fcvm.2025.1638747 Received 31 May 2025 Accepted 29 July 2025 Published 12 August 2025 Volume 12 - 2025 Edited by Alicia Del Saz Lara, University of Castilla-La Mancha, Spain Reviewed by Binaya Basyal, MedStar Washington Hospital Center, United States Taner Ulus, Eskiehir Osmangazi University, Trkiye Updates Copyright 2025 Deng, Li, Li, Li, Cheng and Xiao