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Compatibility is a major factor

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TSNA was detected in the saliva of betel quid with tobacco (BQT) chewers[] and also from chewers of tobacco or only masheri .[] Nicotine and cotinine were found in the saliva and urine of chewers of BQT and in chewers of tobacco only.[] Presence of urinary cotinine was reported in samples from females who used masheri (M) only and those habituated to BQT + M.[] Cotinine was also detected in the gastric fluid of tobacco and lime chewers.[] Excessive occupational exposure to tobacco was evident from a seven-fold increase in inspirable dust particles in the breathing zone of tobacco processors[] and presence of cotinine in urine samples.[] In a solitary study, tobacco exposure was found to elevate excretion of urinary thioethers and glucuronides among bidi rollers.[] A significant reduction in glutathione s-transferase (GST) activity[] and glutathione (GSH) level[] was observed in the lymphocytes of male tobacco chewers female masheri users, respectively

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