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Moreover, it is important to note that after the 12-month study period of the VITAAL II study, the dose of vitamin D in Optimum 2.0 was increased from 7.5 g (150% RDA) to 75 g (1500% RDA)

This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur

Is 250 mcg the same as 0.25 mg