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The widely used 3xTg mouse model, which contains three mutations associated with familial Alzheimers disease, can display anxiety-like behaviors through behavioral paradigms such as the OFT and EPM test as early as 2 months of age (Paciello et al., 2021)

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1 Additionally, glutathione plays a vital role in the detoxification process, aiding in the removal of harmful substances and waste products from the body

Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage